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Once we have sequenced genomes in the previous course, we would like to compare them to determine how species have evolved and what makes them different. In the first half of the course, we will compare two short biological sequences, such as genes (i.e., short sequences of DNA) or proteins. We will encounter a powerful algorithmic tool called dynamic programming that will help us determine the number of mutations that have separated the two genes/proteins. In the second half of the course, we will "zoom out" to compare entire genomes, where we see large scale mutations called genome rearrangements, seismic events that have heaved around large blocks of DNA over millions of years of evolution. Looking at the human and mouse genomes, we will ask ourselves: just as earthquakes are much more likely to occur along fault lines, are there locations in our genome that are "fragile" and more susceptible to be broken as part of genome rearrangements? We will see how combinatorial algorithms will help us answer this question. Finally, you will learn how to apply popular bioinformatics software tools to solve problems in sequence alignment, including BLAST.
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This is the first course in the Learn English: Intermediate Grammar specialization. In this course, you will learn about important intermediate verb tenses,…
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大家好！Hi, everyone, welcome to join our Chinese for HSK Level 3 course. This is CHEN Li and LU Yun, and we are very happy to meet you here! Chinese for HSK 3 i…
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This is it! It is time for YOU to be the journalist, and practice and display the skills you have learned through this Specialization journey. You will creat…
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In the previous course in the Specialization, we learned how to compare genes, proteins, and genomes. One way we can use these methods is in order to constru…
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Do you have to give presentations in school or at your work? Is it nerve-racking? Then you've come to the right place. Everyone gets a little nervous when th…
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Dino 101: Dinosaur Paleobiology is a 12-lesson course teaching a comprehensive overview of non-avian dinosaurs. Topics covered: anatomy, eating, locomotion,…
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In this course, we'll imagine that you are applying for an all-expenses paid, educational trip to a Spanish-speaking nation of your choice. You'll introduce…
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Ready for the big game? Building on the vocabulary and skills that you have already mastered, this third course of the specialization will introduce new voca…
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This Basics of Ethereum course offers a comprehensive exploration of blockchain technology and its applications, equipping you with the skills to navigate th…
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This free online course is one of 10 courses available in the Goldman Sachs 10,000 Women collection, designed for entrepreneurs ready to take their business…
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Complex systems can exhibit emergent phenomena, wherein the interplay of simple underlying rules governing the constituent parts leads to rich and unexpected…
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This course teaches the essentials of big data, from understanding its principles to accessing and using large datasets. You'll learn to explore research que…
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